tRNA-derived small RNAs (tsRNAs), also known as tRNA-derived RNA fragments (tRFs), are newly discovered small non-coding RNAs with diverse functions. We showed that sperm tsRNAs are a type of hereditary factor that contribute to the transmission of epigenetic memory of an acquired metabolic disorder. Read more

Blastomere equality

Sperm RNA

During mammalian early embryo development, how do different lineages emerge? Are 2-cell blastomeres absolutely equal? If not, can there be even small differences at molecular levels? and if so, how do they arise and can they guide future cell fate? Read more
Aquaporin(s), known as water channel(s), were discovered as inert pores that increase cell membrane permeability to water. But are they simply inert pores and why are they so abundant in tissues with low permeability? Might they do something else rather than simply exist as pores? such as in sperm osmoadaptation. Read more

A third eye on AQPs

Fascinated with the resurrected idea of Lamarckism, we study its impacts on our health under modern lifestyles
- the epigenetic inheritance of acquired traits (e.g. metabolic disorders) via germline
Latest Lab News (More news)
2018.6-Our paper of sperm RNA/Dnmt2 -mediated intergenerational transfer of metabolic disorder is highlighted by Nat Rev Endocrinol
2018.5-Kudos! Congratulations to Xudong & Junchao for receiving the Berner Scholarshipto Maya for receiving the Edwards Biology Scholarship & Goldwater National Scholarship Nominee, and to Yunfang for receiving the Ray Wu Prize!  So proud of you all!
2018.5-Our new Perspective with Zernica-Goetz Lab on mammalian embryo symmetry-breaking is published in Nature Communications !
2018.5-SPORTS1.0: our bioinformatic tool with Zhou lab for analyzing tsRNAs/rsRNAs is published in Genomics Proteomics Bioinformatics !
2018.4- Our fantstic team work reporting Dnmt2 is required for sperm small RNA-mediated epigenetic inheritance is online in Nat Cell Biol !
2018.4- Qi Gave seminars at NIH/NIEHS and UC Riverside discussing latest advances in sperm RNAs and RNA modifications.
2018.3- Qi Gave a talk at Wellcome Genome Campus, great meeting for discussing cutting-edge sciences and meeting with friends!
2017.11- Qi gave a talk at CSHA-RNA Modifications & Epitranscriptomics, about new data on sperm RNA modifications, structure & function.
2017.10- Qi gave talks at University of Cambridge & Rank Prize symposium on sperm RNA-mediated epigenetic inheritance.
2017.8- Our Research Highlight on Martienssen lab’s work about tsRNAs in mammalian retrotransposon control is online in Cell Research

THE ONCE AND FUTURE KINGS...

 (designed by Qi Chen Lab) 

  • Once deemed heretical, the idea of “inheritance of acquired characteristics” is now supported by increasing evidence from multiple species, including mammals. We propose that paternally acquired traits (e.g. metabolic disorders) can be “memorized” in the sperm, encoded in the form of RNAs and RNA modifications, and to transmit paternally acquired phenotypes to the offspring via shaping early embryo development (Nat Rev Genet, 2016; Trends Mol Med, 2016)
  • We discovered that tsRNAs (tRNA-derived small RNAs) are enriched in the mature sperm (Cell Res, 2012) and serum (JMCB, 2014) with evolutionary conservation; and that sperm tsRNAs can act as epigenetic factor in mediating intergenerational inheritance of acquired traits (Science, 2016), which require the action of Dnmt2 (Nat Cell Biol, 2018)

The Evolving Ideas of Heredity & Hereditary Information Carriers